Latent Space: The AI Engineer Podcast

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space Sponsorship and business inquiries: business@latent.space www.latent.space

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Most frequent guests

Simon Willison 4 episodes
Nathan Lambert 4 episodes
Logan Kilpatrick 2 episodes
Deedy Das 2 episodes
Joseph Nelson 2 episodes
Jeremy Howard 2 episodes
Mike Conover 2 episodes
Yi Tay 2 episodes

Every guest on Latent Space: The AI Engineer Podcast

202 guests, ranked by how many people never want them back.

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Marc Andreessen
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different" · Apr 2026

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Aravind Srinivas

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Dylan Patel
The State of Silicon and the GPU Poors - with Dylan Patel of SemiAnalysis · Nov 2023

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Ilya Sutskever

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Satya Nadella
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build · Jun 2026

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Joscha Bach
WebSim, WorldSim, and The Summer of Simulative AI — with Joscha Bach of Liquid AI, Karan Malhotra of Nous Research, Rob Haisfield of WebSim.ai · Apr 2024

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George Hotz
Commoditizing the Petaflop — with George Hotz of the tiny corp · Jun 2023

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Chris Lattner
Doing it the Hard Way: Making the AI engine and language 🔥 of the future — with Chris Lattner of Modular · Sep 2023

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Noam Brown
Scaling Test Time Compute to Multi-Agent Civilizations — Noam Brown, OpenAI · Jun 2025

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Fei Fei Li
After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs · Nov 2025

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Martin Casado
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z · Feb 2026

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Noah Smith

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Aaron Levie
Every Agent Needs a Box — Aaron Levie, Box · Mar 2026

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Anastasios Angelopoulos
[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena · Jan 2026

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Anjney Midha
The Professor of Outputmaxxing — Anjney Midha, AMP · Jun 2026

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Bret Taylor
The AI Architect — Bret Taylor · Feb 2025

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David Hsu
Why StackOverflow usage is down 50% — with David Hsu of Retool · Feb 2024

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David Luan
Why Google failed to make GPT-3 + why Multimodal Agents are the path to AGI — with David Luan of Adept · Mar 2024

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David Singleton
Dreamer: the Personal Agent OS — David Singleton · Mar 2026

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Dharmesh Shah
The Agent Network — Dharmesh Shah · Mar 2025

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Drew Houston
Building the Silicon Brain - with Drew Houston of Dropbox · Oct 2024

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Dylan Field
Taste is your Moat (Dylan Field of Figma) · Oct 2025

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Eiso Kant
Inside the Model Factory — Eiso Kant, Poolside AI · Jul 2026

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Janie Lee
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge · May 2026

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Joon Sung Park
Simulation: the new Scaling Law — Joon Sung Park, Simile AI · Aug 2026

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Karina Nguyen
The Agent Reasoning Interface: o1/o3, Claude 3, ChatGPT Canvas, Tasks, and Operator — with Karina Nguyen of OpenAI · Feb 2025

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Logan Kilpatrick
Emergency Pod: ChatGPT's App Store Moment (w/ OpenAI's Logan Kilpatrick, LindyAI's Florent Crivello and Nader Dabit) · 2 episodes

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Mikey Shulman
Making Transformers Sing - with Mikey Shulman of Suno · Mar 2024

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Qasar Younis
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition · Apr 2026

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Richard Socher
Humanity’s Last Invention — Richard Socher of Recursive · Sep 2026

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Sam Schillace
Presenting the AI Engineer World's Fair — with Sam Schillace, Deputy CTO of Microsoft · Mar 2024

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Shreya Shankar
Grounded Research: From Google Brain to MLOps to LLMOps — with Shreya Shankar of UC Berkeley · Mar 2023

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Simon Willison
[Ride Home] Simon Willison: Things we learned about LLMs in 2024 · 4 episodes

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Varun Mohan
97% Cheaper, Faster, Better, Correct AI — with Varun Mohan of Codeium · Mar 2023

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Alex Lieberman
⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex · Nov 2025

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Kanjun Qiu
Why AI Agents Don't Work (yet) - with Kanjun Qiu of Imbue · Oct 2023

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Doug O'Laughlin
Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis · Feb 2026

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Jack Morris
Information Theory for Language Models: Jack Morris · Jul 2025

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Deedy Das
Anthropic, Glean & OpenRouter: How AI Moats Are Built with Deedy Das of Menlo Ventures · 2 episodes

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Harrison Chase
The Point of LangChain — with Harrison Chase of LangChain · Sep 2023

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Recent episodes

223 episodes from the feed, newest first.

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC
with Rune Kvist

Sep 2026
Humanity’s Last Invention — Richard Socher of Recursive
with Richard Socher

Sep 2026
🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
with Anima Anandkumar

Aug 2026
Simulation: the new Scaling Law — Joon Sung Park, Simile AI
with Joon Sung Park

Aug 2026
🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
with Matthew McPartlon

Aug 2026
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
with Philip Kiely

Aug 2026
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
with Akshay Nathan

Jul 2026
Inside the Model Factory — Eiso Kant, Poolside AI
with Eiso Kant

Jul 2026
🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
with Bo Wang

Jul 2026
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
with Andy Beam

Jul 2026
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
with Akshat Bubna

Jul 2026
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
with Evan Feinberg

Jul 2026
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
with Matei Zaharia

Jun 2026
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
with Zico Kolter

Jun 2026
The Professor of Outputmaxxing — Anjney Midha, AMP
with Anjney Midha

Jun 2026
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
with Joseph Krause

Jun 2026
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
with Lukas Petersson

Jun 2026
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
with Carina Hong

Jun 2026
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
with Satya Nadella

Jun 2026
GitHub's plan for Agents — Kyle Daigle, GitHub
with Kyle Daigle

Jun 2026
Why Video Agent models are next — Ethan He, xAI Grok Imagine
with Ethan He

Jun 2026
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
with Walden Yan

May 2026
🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
with Alex Rives

May 2026
Giving Agents Computers — Ivan Burazin, Daytona
with Ivan Burazin

May 2026
Railway: The Agent-Native Cloud — Jake Cooper
with Jake Cooper

May 2026