Mind & Matter

Weekly science podcast by neuroscientist Nick Jikomes, PhD. Long-form interviews with researchers on the brain, nutrition, metabolism, drugs and aging. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs:

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Every guest on Mind & Matter

280 guests, ranked by how many people never want them back.

1. —
   Giles Yeo

   Body Weight Is 40-70% Heritable. Here's What That Doesn't Mean | Giles Yeo | 222 · Apr 2025

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   Never again
2. —
   Gül Dölen

   Five Psychedelics Reopened a Social Learning Window in Adult Mice | Gül Dölen | 121 · 2 episodes

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   Never again
3. —
   Heather Heying

   Dating Apps Give 20% of Men 80% of Women's Interest | Heather Heying & Bret Weinstein | 36 · Sep 2021

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   Never again
4. —
   Joanna Moncrieff

   Antidepressants Beat Placebo by About 2 Points on a 52-Point Scale | Joanna Moncrieff | 88 · Sep 2022

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   Never again
5. —
   Kevin J. Tracey

   Your Vagus Nerve Can Switch Off Inflammation | Kevin Tracey | 288 · Apr 2026

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6. —
   Luc van Loon

   A 100-Gram Protein Meal Beat 25 Grams for Muscle Protein Synthesis | Luc van Loon | 148 · 2 episodes

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7. —
   Matt Kaeberlein

   Resveratrol Never Lived Up to the Red Wine Longevity Story | Matt Kaeberlein | 151 · Apr 2024

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8. —
   Nicholas Wade

   SARS-CoV-2 Lacks the Telltale Signs of a Natural Origin, He Argues | Nicholas Wade | 39 · Sep 2021

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9. —
   Thomas Seyfried

   Is Cancer a Metabolic Disease, Not a Genetic One? | Thomas Seyfried | 224 · Apr 2025

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10. —
    Boris Heifets

    Psychedelic Trials Can't Truly Be Blinded. Why That Matters | Boris Heifets | 163 · Jun 2024

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11. —
    John Ioannidis

    Most Published Research Findings Are False, and the Math Still Holds | John Ioannidis | 212 · Mar 2025

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12. —
    Judith Curry

    Hurricanes Aren't Getting More Frequent. The Debate Is Over Intensity | Judith Curry | 84 · Aug 2022

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13. —
    Kevin Mitchell

    If Your Identical Twin Has Schizophrenia, Your Own Risk Is About 50% | Kevin Mitchell | 78 · Jul 2022

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14. —
    Rachel Yehuda

    Most People Exposed to Trauma Never Develop PTSD | Rachel Yehuda | 67 · Apr 2022

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15. —
    Martin Kulldorff

    Sweden Avoided Lockdowns and Saw Lower Excess Mortality | Martin Kulldorff | 210 · 2 episodes

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16. —
    Sean B. Carroll

    New Body Forms Evolve by Rewiring Gene Switches, Not New Genes | Sean B. Carroll | 138 · 2 episodes

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17. —
    Joseph LeDoux

    The Amygdala Detects Threats. The Feeling of Fear Comes Later, He Says | Joseph LeDoux | 73 · Jun 2022

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18. —
    Emeran Mayer

    About 70% of Your Immune Cells Live in Your Gut | Emeran Mayer | 24 · May 2021

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19. —
    John Cryan

    A Young Mouse's Microbiome Reversed Some Signs of Brain Aging in Old Mice | John Cryan | 63 · Mar 2022

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20. —
    Alexis Cowan

    Sunlight Curbs Appetite Through a Hormone Unrelated to Vitamin D | Alexis Cowan | 287 · Apr 2026

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21. —
    George Church

    Genome Sequencing Fell From $3 Billion to Under $1,000 | George Church | 27 · Jun 2021

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22. —
    Jack Kruse

    He Lost 133 Pounds in 11 Months With Sunlight and Cold. His Theory | Jack Kruse | Episode 221 · Apr 2025

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23. —
    Kevin McKernan

    Pfizer's Vaccine Plasmid Carries Four SV40 Virus Components | Kevin McKernan | 196 · 3 episodes

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24. —
    Mark Mattson

    After 12 to 14 Hours Without Food, Your Body Switches to Ketones | Mark Mattson | 139 · Feb 2024

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25. —
    Nick Norwitz

    Oreos Lowered His LDL Twice as Much as a Statin. What It Means | Nick Norwitz | 195 · Oct 2024

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26. —
    Ronald Krauss

    A Low-Fat, High-Carb Diet Shifted 1 in 4 People to Riskier Small LDL | Ronald Krauss | 131 · Dec 2023

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27. —
    Lee Berger

    Homo Naledi Had a Tiny Brain Yet May Have Buried Its Dead | Lee Berger | 38 · Sep 2021

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28. —
    Leroy Hood

    Much Chronic Disease Could Be Caught and Prevented Before Symptoms | Lee Hood | 205 · Jan 2025

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29. —
    Richard Johnson

    Your Body Makes Fructose From Glucose, and It Turns On Fat Storage | Richard Johnson | 295 · Jun 2026

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30. —
    Stephan van Vliet

    Most of What's in Your Food Isn't on the Nutrition Label | Stephan van Vliet | 273 · Jan 2026

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31. —
    Ziva Cooper

    Cannabis Use Has Jumped Over 400% Among People 55 and Older | Ziva Cooper | 15 · Mar 2021

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32. —
    Manoj Doss

    MDMA Can Make It Harder to Read Fear in Other People's Faces | Manoj Doss | 74 · Jun 2022

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33. —
    Manvir Singh

    Shamanism Appears Across Cultures. It's Not Just Early Religion | Manvir Singh | 219 · Apr 2025

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34. —
    Nicola Segata

    Mothers Pass Gut Microbes to Their Babies at Birth | Nicola Segata | 203 · Jan 2025

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35. —
    Philip Calder

    Inflammation Doesn't Just Fade. Omega-3s Help Your Body Switch It Off | Philip Calder | 291 · May 2026

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36. —
    Robert Lufkin

    He Taught Medical Students Things He Now Says Were Wrong | Robert Lufkin | 157 · May 2024

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37. —
    Suzanne Devkota

    Probiotics After Antibiotics Can Delay Your Gut's Natural Recovery | Suzanne Devkota | 56 · Feb 2022

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38. —
    Tucker Goodrich

    Oxidized Seed Oil Fats May Matter More for Heart Disease Than LDL | Tucker Goodrich | 244 · 2 episodes

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39. —
    George Davey-Smith

    Why Observational Studies Keep Getting Nutrition Wrong | George Davey Smith | 265 · Dec 2025

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    Never again
40. —
    Momo Vuyisich

    The Same Food Can Help One Person and Harm Another | Momo Vuyisich | 204 · Jan 2025

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    Never again