The a16z Show

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

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Every guest on The a16z Show

694 guests, ranked by how many people never want them back.

1. —
   Jensen Huang

   Jensen Huang and Arthur Mensch on Winning the Global AI Race · Mar 2025

   0 votes

   Never again
2. —
   Andrew Huberman

   Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity · Mar 2026

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3. —
   Mark Cuban

   Mark Cuban on the NBA, Cost Plus Drugs, and How to Fix Politics · 3 episodes

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4. —
   Sam Altman

   Sam Altman on Sora, Energy, and Building an AI Empire · Oct 2025

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5. —
   David Senra

   Marc Andreessen on the Mindset of Great Founders — with David Senra · Mar 2026

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6. —
   Jake Paul

   Jake Paul & Anti Fund: From Creator to Investor · Jun 2026

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7. —
   Greg Brockman

   Greg Brockman on Why OpenAI Says We’re Entering the AGI Era · Sep 2026

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8. —
   Benedict Evans

   AI Eats the World? A Reality Check with Benedict Evans · 16 episodes

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9. —
   Dylan Patel

   From the Archive: Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure · 3 episodes

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10. —
    Ryan Greenblatt

    Why 1,200 AI Agents Started Working Together | Ryan Greenblatt · Aug 2026

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11. —
    Mark Zuckerberg

    Mark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease · 2 episodes

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12. —
    Tyler Cowen

    Tyler Cowen & Alex Tabarrok on AI, Jobs, and Economic Growth · 4 episodes

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13. —
    Patrick Collison

    Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding · 2 episodes

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14. —
    Balaji Srinivasan

    Balaji Srinivasan: Prove Correct, Not Just Go Direct · 7 episodes

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15. —
    Brian Armstrong

    Ben Horowitz and Brian Armstrong on Building and Overcoming the Hard Things · 2 episodes

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16. —
    Joe Rogan

    Marc Andreessen on AI, California, and the Future of America | Joe Rogan · May 2026

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17. —
    Robin Hanson

    Robin Hanson on Prediction Markets, Gambling, and the Future of Forecasting · May 2026

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18. —
    Rick Rubin

    Rick Rubin on AI, Creativity, and The Way of Code · 2 episodes

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19. —
    Jay Bhattacharya

    America's Autism Crisis and How AI Can Fix Science with NIH Director Jay Bhattacharya · Sep 2025

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20. —
    Neal Stephenson

    Neal Stephenson on The Future of the Metaverse · Nov 2022

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21. —
    Vitalik Buterin

    Vitalik Buterin on Human Agency in the AI Era · 2 episodes

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22. —
    Dmitri Dolgov

    The System Behind Self-Driving: Waymo’s Dmitri Dolgov · 2 episodes

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23. —
    Joe Lonsdale

    Marc Andreessen and Joe Lonsdale on Tariffs and Trade · Jul 2025

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24. —
    Tony Robbins

    The Future of Longevity with Tony Robbins · Dec 2023

    0 votes

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25. —
    Kevin Kelly

    The Truth about 1000 True Fans + Pricing Our Attention · 3 episodes

    0 votes

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26. —
    Andrew Chen

    What It Takes to Build a Startup | Andrew Chen & Matt Perault · 10 episodes

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27. —
    Kamala Harris

    a16z Podcast: Taking the Measure of Tech in Policy -- with Kamala Harris · Jun 2017

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28. —
    David Oyelowo

    a16z Podcast: Mastering the Game (with David Oyelowo) · Sep 2016

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29. —
    Fei Fei Li

    Fei Fei Li: The Race to Build World Models For AI · 8 episodes

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30. —
    Reid Hoffman

    Reid Hoffman on AI, Consciousness, and the Future of Humanity · Oct 2025

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31. —
    Shonda Rhimes

    Shonda Rhimes on How to Create Stories (and Products) People Want · Dec 2019

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32. —
    Aly Raisman

    Transitioning From Gymnast to Investor with Aly Raisman · Jul 2024

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33. —
    Alex Tabarrok
    0 votes

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34. —
    Dan Wang

    Balaji and Dan Wang: The Engineering State vs Lawyerly State · 2 episodes

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35. —
    Joel Mokyr

    a16z Podcast: Knowledge Builds Technology and Technology Builds Knowledge -- with Joel Mokyr · Nov 2016

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36. —
    Martin Casado

    The Infrastructure Behind the Machine Age · 18 episodes

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37. —
    Taylor Lorenz

    Balaji and Taylor Lorenz on AI and Media · May 2026

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38. —
    Alex Honnold

    Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship · 2 episodes

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39. —
    Lloyd Blankfein

    Lloyd Blankfein on Risk, Crisis, and Leadership · May 2026

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40. —
    Noah Smith

    Dwarkesh and Noah Smith on AGI and the Economy · Aug 2025

    0 votes

    Never again