This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

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Every guest on This Week in Startups

888 guests, ranked by how many people never want them back.

1. —
   Jensen Huang
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2. —
   Derek Thompson

   Shopify Board proposes share restructuring + The Atlantic's Derek Thompson, Why American Teens Are So Sad | E1433 · Apr 2022

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3. —
   Aravind Srinivas

   Creating the future of search and competing vs Google with Perplexity AI's Aravind Srinivas | E1770 · Jun 2023

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4. —
   Mark Cuban

   Mark Cuban on the resurgence of retail investors, NBA's potential entry into wagering & digital assets, DeFi & much more | Angel S5 E5 · Feb 2021

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5. —
   David Friedberg

   David Friedberg on AI-First Startups & the Future of Biology, Business & Creativity | AI Basics with Google Cloud · 2 episodes

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6. —
   Will Guidara

   Lessons in Unreasonable Hospitality with Will Guidara | E1966 · Jun 2024

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7. —
   Bill Gurley

   Bill Gurley, Brad Gerstner, & Jason Calacanis on the state of tech markets, hosted by David Weisburd | E1875 · 2 episodes

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8. —
   JD Vance

   Behind the scenes at the ALL-IN AI SUMMIT w/ POTUS, JD Vance, Jensen Huang, Lisa Su, and more… | E2156 · Jul 2025

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9. —
   Rory Sutherland

   Rory's brain vs ChatGPT, outrageous marketing, work trends and MUCH more w/ Rory Sutherland | E1756 · 2 episodes

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10. —
    Chris Lattner

    Expanding AI chip capabilities beyond Nvidia with Modular CEO Chris Lattner | E1808 · Sep 2023

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11. —
    Stephen Wolfram

    Stephen Wolfram on AI's rapid progress & the "Post-Knowledge Work Era" | E1711 · Mar 2023

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12. —
    Tim Urban

    Tim Urban on the path to AGI and trends in tech history | E1779 · Jul 2023

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13. —
    Chamath Palihapitiya

    Chamath on why young people need more agency, risk, and adventure · 4 episodes

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14. —
    Balaji Srinivasan

    Rebuilding Civilization from First Principles: Inside Balaji's Network State Vision | E2145 · 2 episodes

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15. —
    Brian Armstrong

    Throwback! Coinbase CEO Brian Armstrong from November 2017 · Apr 2021

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16. —
    Anthony Pompliano

    E1078 Pomp Podcast Crossover: Anthony "Pomp" Pompliano on most exciting crypto projects, Hey vs. Apple, Robinhood/Barstool traders, Zuck vs. Bezos, Jason's Bitcoin position & more! · Jun 2020

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17. —
    Eugenia Kuyda

    How AI companions can help solve loneliness with Replika's Eugenia Kuyda | E1758 · Jun 2023

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18. —
    Daphne Koller

    E1089 The Next Unicorns E11: insitro CEO Daphne Koller is revolutionizing drug discovery via machine learning & data, shares insights on remote education from time at Coursera & more · Jul 2020

    0 votes

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19. —
    Jonathan Swanson

    Getting past the "Cardinal Sins of Delegating" with Jonathan Swanson of Athena | E2218 · Dec 2025

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20. —
    Dwarkesh Patel

    Twitter funding secured, Boring Co. raises $675M, Amazon's $1B VC fund, Ackman's $400M loss + The Lunar Society: Dwarkesh Patel | E1441 · Apr 2022

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21. —
    Joe Lonsdale

    BAYC at Sotheby's, Loot, Tether Canada ban + 8VC's Joe Lonsdale: Palantir, China, Cicero | E1278 · Sep 2021

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22. —
    Charles Duhigg

    The power of super communication with Charles Duhigg | E1938 · Apr 2024

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23. —
    Andrew Wilkinson

    Andrew Wilkinson on bringing the Buffett approach to startups, WeCommerce, Slack & more | E1174 · Feb 2021

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24. —
    Reeves Wiedeman

    Best of This Week in Startups: Week of October 26th, 2020 · 2 episodes

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25. —
    Mike O'Brien

    $NFLX earnings, Reed Hastings steps down, Google's 6% RIF & Ok Boomer with Mike O'Brien | E1662 · Jan 2023

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26. —
    Reid Hoffman

    Reid Hoffman on AI's "crescendo moment," regulation and real-world applications | E1739 · 2 episodes

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27. —
    Mustafa Suleyman

    Inflection AI CEO Mustafa Suleyman on building modern AI, DeepMind origins, and much more | E1794 · Aug 2023

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28. —
    Brian Chesky

    Airbnb CEO Brian Chesky on early rejection, customer focus & AI's future in hospitality | E1735 · May 2023

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29. —
    Erin Meyer

    No Rules Rules Co-Author Erin Meyer: Netflix's "keeper test", comparative turnover, navigating global business cultures – Part 2 | E1168 · 2 episodes

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30. —
    Anne Wojcicki

    Genomes Unlocked: Anne Wojcicki's Vision for 23andMe and the Future of Proactive Healthcare | E1858 · Dec 2023

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31. —
    Ben Smith

    BuzzFeed vs Gawker, AI's impact on the future of media, and more with Semafor's Ben Smith | E1733 · May 2023

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32. —
    Celine Halioua

    Next Unicorns: Developing drugs to extend dog lifespans with Loyal CEO Celine Halioua | E1799 · Aug 2023

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33. —
    Chris Urmson

    Aurora CEO Chris Urmson on building the roadmap to fully autonomous vehicles | E1228 · Jun 2021

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34. —
    Daryl Morey

    E1155: Daryl Morey on his eventful 2020, adapting to paradigm shifts, taking the Sixers job, building a winning organization & more · Dec 2020

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35. —
    Max Chafkin

    Coinbase chases NFT billions + Peter Thiel "The Contrarian" with author Max Chafkin | E1305 · Oct 2021

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36. —
    Scott Farquhar

    Bootstrapping to IPO, product-led growth, & scaling SaaS with Atlassian's Scott Farquhar | E1800 · Sep 2023

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37. —
    Taylor Lorenz

    Facebook funding anti-TikTok lobbyists with Taylor Lorenz + SEC SPAC crackdown, Fast vs. Bolt | E1422 · 2 episodes

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38. —
    Zeke Faux

    Inside crypto's wild rise and fall with "Number Go Up" author Zeke Faux | E1807 · 2 episodes

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39. —
    Alexis Ohanian

    Alexis Ohanian on Reddit's potential IPO & more | E1893 · 2 episodes

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40. —
    Anthony Casalena

    Facebook puts Instagram Kids on pause, Bevy's high-profile firing + Squarespace's Anthony Casalena | E1291 · Sep 2021

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