This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

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Every guest on This Week in Startups

888 guests, ranked by how many people never want them back.

1. —
   Anastasios Angelopoulos

   How the 1% Will Own Compute (and What It Means for You) · May 2026

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2. —
   Ben Lerer
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3. —
   Brendan Foody
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4. —
   Gavin Uberti

   23andMe BANKRUPT, Saylor Still Buying Bitcoin, + Founder Interviews | E2102 · Mar 2025

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5. —
   Gili Raanan
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6. —
   Hiten Shah

   Will OpenAI Tank OpenClaw? | E2251 · Feb 2026

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7. —
   Hussein Kanji
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8. —
   Jeff Morris Jr
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9. —
   Jesse Genet
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10. —
    John Harris

    Manufacturing in the US, Building in Open Source… and more | E2154 · Jul 2025

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11. —
    Lo Toney
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12. —
    Matt Turck
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13. —
    Mike Maples
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14. —
    Nikhil Basu Trivedi

    Why Data Is the Next $1 Trillion Market · Jul 2026

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15. —
    Niko Bonatsos
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16. —
    Sheel Mohnot

    Bill Gates foresees massive AI job loss: these VCs disagree | E2330 · Aug 2026

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17. —
    Spenser Skates

    Anatomy of a Win-Win Acquisition: Synergy, Growth, AI, and the Future of SaaS | E2047 · Nov 2024

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18. —
    Alex Oshmyansky

    Solving prescription drug pricing in the US with Cost Plus Drugs & Capital RX CEOs | E1518 · Jul 2022

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19. —
    Dave Ferguson

    Uber, Lucid & Nuro team up on robotaxis by 2026 | E2173 · Sep 2025

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20. —
    Augustus Doricko

    Cloud Seeding, Conspiracies & the Texas Floods | BONUS EPISODE! · Jul 2025

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21. —
    David Rodriguez

    E991: #StartupTuneup with Urban-X: Waste-reducing marketplaces, traffic liability reduction, recreational sharing spaces, firefighter safety software & energy cost saving AI · Oct 2019

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22. —
    Tom Mueller

    The project SpaceX's first employee raised $500M for · Jun 2026

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23. —
    James Evans
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24. —
    Gabe Pereyra

    Inside Harvey AI's $8 billion AI lawyer app, PLUS How OpenRouter unites the LLMs | E2207 · Nov 2025

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25. —
    Anastasis Germanidis
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26. —
    Katelin Holloway

    VC experts on why Physical AI funding is heating up | E2333 · Sep 2026

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27. —
    Adeel Khan

    Magic School uses AI to help kids learn, not cheat | E2196 · Oct 2025

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28. —
    Alex Kendall

    The Self-Driving Startup Nobody Saw Coming | E2289 · 2 episodes

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29. —
    Alex Shieh

    How to Make Billions from Exposing Fraud | E2234 · Jan 2026

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30. —
    Chris Hladczuk

    $100T is managed by "human duct tape" | E2308 · Jul 2026

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31. —
    Dean Leitersdorf

    Decart makes AI faster, Lume teaches lamps to fold laundry | E2166 · Aug 2025

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32. —
    James Cadwallader

    Profound, Resistant AI & OpenAI's Economic Pitch | E2071 · Jan 2025

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33. —
    Kevin Gibbon

    These robots could cut delivery costs by 80% | Next Unicorns · Aug 2026

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34. —
    Manny Medina

    How Founders Are Building the Next Great Startups | Paid.ai, iTruckr & Tenax AI | E2175 · Sep 2025

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35. —
    Philip Johnston
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36. —
    Shensi Ding

    Merge's Unified API Bet in the AI Era | E2033 · Oct 2024

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37. —
    Tim Ranzetta

    Starlink + Tesla? $4T Nvidia? Perplexity Browser? Linda Yaccarino Steps Down? | E2149 · Jul 2025

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38. —
    Tony Stubblebine

    Why Medium is HIDING from AI | E2179 · Sep 2025

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39. —
    Erik Voorhees

    Is Anthropic Making the Biggest Mistake in AI History | E2258 · Mar 2026

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40. —
    Ryan Carson

    3 AI Agents That Actually Replaced Human Jobs | E2272 · 2 episodes

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