Mind & Matter

Weekly science podcast by neuroscientist Nick Jikomes, PhD. Long-form interviews with researchers on the brain, nutrition, metabolism, drugs and aging. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs:

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Every guest on Mind & Matter

280 guests, ranked by how many people never want them back.

1. —
   Greg Steinberg

   The Enzyme That Fasting, Exercise, Metformin & Ozempic All Switch On | Greg Steinberg | 276 · Jan 2026

   0 votes

   Never again
2. —
   Gregory Scherrer

   Blocking Opioid Receptors Shrinks the Placebo Effect | Gregory Scherrer | 177 · Sep 2024

   0 votes

   Never again
3. —
   György Buzsáki

   Your Memories Aren't Fixed Recordings in the Brain | György Buzsáki | 228 · May 2025

   0 votes

   Never again
4. —
   Gábor Somlyai

   Can Water Low in Deuterium Slow Cancer? | Gábor Somlyai | 297 · Jun 2026

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   Never again
5. —
   Iain Oswald

   Skunky Cannabis Smell Comes From Sulfur Compounds, Not Terpenes | Iain Oswald | 167 · 2 episodes

   0 votes

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6. —
   Isaac Chiu

   Pain, Inflammation, Peptides & Healing | Isaac Chiu | 303 · Aug 2026

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7. —
   Isaac Harris

   Antioxidant Supplements Raised Cancer Rates in Major Trials. Here's Why | Isaac Harris | 296 · Jun 2026

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8. —
   Jacob Raber

   Your ApoE Gene Changes How Your Brain Handles Stress, Diet and Radiation | Jacob Raber | 254 · Sep 2025

   0 votes

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9. —
   Javier González-Maeso

   Psychedelics Hit Female Mice Harder but Helped Males More | Javier González-Maeso | 277 · Feb 2026

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10. —
    Jeff Ubersax

    He Engineers Yeast to Brew Cannabinoids Without the Plant | Jeff Ubersax | 14 · Mar 2021

    0 votes

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11. —
    Jens Lund

    Why Some People Stay Thin Even When They Overeat | Jens Lund | 284 · Mar 2026

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12. —
    Jessica Rose

    Myocarditis and Menstrual Changes Stand Out in mRNA Shot VAERS Data | Jessica Rose | 198 · Dec 2024

    0 votes

    Never again
13. —
    Jibran Khokhar

    Cannabis Can Trigger a Real, Drug-Induced Psychosis | Jibran Khokhar | 190 · Nov 2024

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14. —
    Jim Chatters
    0 votes

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15. —
    Joe Baur

    Resveratrol Extended Life Only in Obese Mice, Not Healthy Ones | Joe Baur | 64 · Mar 2022

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16. —
    John Blenis
    0 votes

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17. —
    John Hawks

    A Species With a Third of Our Brain Size May Have Buried Its Dead | John Hawks | 126 · 2 episodes

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18. —
    John Speakman

    Diet Surveys Undercount What People Eat, Skewing Nutrition Science | John Speakman | 225 · 2 episodes

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19. —
    Jon Brestoff

    Your Cells Swap Mitochondria, and High-Fat Diets Disrupt It | Jon Brestoff | 261 · Nov 2025

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20. —
    Jon Kostakopoulos

    Six Years After a Psilocybin Trial, He Still Hasn't Had a Drink | Jon Kostakopoulos | 23 · May 2021

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21. —
    Jon Page

    Cannabis Dependency Hits About 9% of Regular Users, Like Caffeine | Jon Page | 5 · Jan 2021

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22. —
    Jonathan Schaefer

    The Twin Who Used More Cannabis Showed No Extra Psychosis Signs | Jonathan Schaefer | 49 · Dec 2021

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23. —
    Jonny Kohl

    Pregnancy Hormones Rewire the Brain for Parenting | Jonny Kohl | 262 · Nov 2025

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24. —
    Joseph Bass

    Why Eating at the Wrong Time of Day Adds Weight | Joseph Bass | 281 · Feb 2026

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25. —
    Joseph Takahashi

    Meal Timing Tripled Calorie Restriction's Lifespan Gain in Mice | Joseph Takahashi | 237 · Jul 2025

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26. —
    Joshua Siegel

    Psilocybin Knocks Brain Cells Out of Sync With Their Neighbors | Joshua Siegel | 188 · Nov 2024

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27. —
    June Round

    Mice Missing Certain Gut Bacteria Gained Weight Faster | June Round | 178 · Sep 2024

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28. —
    Justin Perry

    Too Much Fructose Impaired Brain Cleanup, Caused Anxiety in Young Mice | Justin Perry | 249 · Sep 2025

    0 votes

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29. —
    Katrin Preller

    Block the 5-HT2A Receptor and a Classic Psychedelic Stops Working | Katrin Preller | 8 · Feb 2021

    0 votes

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30. —
    Katrin Svensson

    Ozempic Reaches Your Brain in Ways Your Own GLP-1 Can't | Katrin Svensson | 298 · Jun 2026

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31. —
    Kent Berridge

    Rats With 99% of Their Dopamine Gone Still Liked Sweet Tastes | Kent Berridge | 94 · Oct 2022

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32. —
    Kimber Stanhope

    What we're getting WRONG about cane sugar & corn syrup | Kimber Stanhope | 307 · Sep 2026

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33. —
    Kristin Stanford

    Parents' Exercise Improves Offspring Metabolism via Sperm and Milk | Kristin Stanford | 289 · Apr 2026

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34. —
    Leighton Woodhouse

    Homelessness Nonprofits Develop an Interest in Surviving, He Says | Leighton Woodhouse | 87 · Sep 2022

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35. —
    Leonard Guarente

    The Best Anti-Aging Fixes Extend Mouse Lifespan Only 10 to 30% | Leonard Guarente | 69 · May 2022

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36. —
    Lisa Monteggia

    Ketamine Lifts Depression in Hours, While SSRIs Take Weeks | Lisa Monteggia | 29 · Jul 2021

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37. —
    Louis Ptáček

    The Fats You Eat Change How Fast Your Body Clock Adjusts | Louis Ptáček | 268 · Dec 2025

    0 votes

    Never again
38. —
    Louise Hecker

    Psilocybin Extended Cell Lifespan and Helped Old Mice Live Longer | Louise Hecker | 252 · Sep 2025

    0 votes

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39. —
    Luis Felipe Barros

    Why Your Brain Is Far More Energy-Efficient Than Any Computer | Luis Felipe Barros | 264 · Nov 2025

    0 votes

    Never again
40. —
    Luis de Lecea

    A Predator Nearby Switches Off Sleep Through the Stress System | Luis de Lecea | 168 · Aug 2024

    0 votes

    Never again