No Priors

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

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Most frequent guests

Jensen Huang 3 episodes
Andrej Karpathy 2 episodes
Noam Brown 2 episodes
Andrew Feldman 2 episodes
Jesse Zhang 2 episodes
Sridhar Ramaswamy 2 episodes
Jacob Helberg 2 episodes
Tuhin Srivastava 2 episodes

Every guest on No Priors

150 guests, ranked by how many people never want them back.

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Jensen Huang
NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative · 3 episodes

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Aravind Srinivas
How do we go from search engines to answer engines? With Perplexity AI’s Aravind Srinivas and Denis Yarats · Mar 2023

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Winston Weinberg
How Harvey AI is Changing the Legal Industry with Winston Weinberg · Feb 2025

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Joe Liemandt
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt · Sep 2025

0 votes
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Dylan Patel
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel · Aug 2025

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Ilya Sutskever
What is Digital Life? with OpenAI Co-Founder & Chief Scientist Ilya Sutskever · Nov 2023

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Andrej Karpathy
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI · 2 episodes

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Mark Zuckerberg
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives · Jun 2026

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Noam Shazeer
Your AI Friends Have Awoken, With Noam Shazeer · Apr 2023

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Jared Kushner
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI · Sep 2025

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Noam Brown
Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown · 2 episodes

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Brian Armstrong
Coinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong · Sep 2026

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Oriol Vinyals
Google DeepMind's Vision for AI, Search and Gemini with Oriol Vinyals from Google DeepMind · Aug 2024

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Daphne Koller
How AI can make drug discovery fail less, with Daphne Koller from Insitro · Mar 2023

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Andrew Ng
How Agentic AI is Transforming The Startup Landscape with Andrew Ng · Aug 2025

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Fei Fei Li
Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs · Jun 2025

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Mustafa Suleyman
Will Everyone Have a Personal AI? With Mustafa Suleyman, Founder of DeepMind and Inflection · May 2023

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Glenn Fogel
Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel · Jul 2026

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Ivan Zhao
RAG is the key for smarter productivity tools with Notion CEO Ivan Zhao · Feb 2024

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Kevin Scott
Going Full Send on AI, and the (Positive) Impact of AI on Jobs, with Kevin Scott, CTO of Microsoft · May 2023

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Matt Garman
Cloud Strategy in the AI Era with Matt Garman, CEO of AWS · Aug 2024

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RJ Scaringe
Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe · Feb 2026

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Rene Haas
Redefining Chip Architecture with Arm CEO Rene Haas · Sep 2026

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Rick Caruso
Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward · Jan 2025

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Sal Khan
The AI Tutor For Every Child and the Next Frontier of Education, From Khan Academy’s Creator Sal Khan · Aug 2023

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Thomas Dohmke
Copilot, Agent Mode, and the New World of Dev Tools with GitHub’s CEO Thomas Dohmke · Mar 2025

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Aidan Gomez
Model Plateaus and Enterprise AI Adoption with Cohere's Aidan Gomez · Nov 2024

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Alexandr Wang
The Data Foundry for AI with Alexandr Wang from Scale · May 2024

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Amjad Masad
How Replit’s AI Tools are Changing Software Development with Co-founder and CEO Amjad Masad · Sep 2023

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Andrew Feldman
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman · 2 episodes

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Arthur Mensch
Mistral 7B and the Open Source Revolution With Arthur Mensch, CEO Mistral AI · Nov 2023

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Arvind Jain
AI is Making Enterprise Search Relevant, with Arvind Jain of Glean · May 2025

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Ben Mann
Will we have Superintelligence by 2028? With Anthropic’s Ben Mann · Jun 2025

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Bill Clerico
What Can We Do About Wildfires? With Convective Capital’s Bill Clerico · Jan 2025

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Brendan Foody
From Job Displacement to AI Trainers, Brendan Foody on Work in the AI Age · Apr 2025

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Bret Taylor
Transforming Customer Service through Company Agents, with Sierra’s Bret Taylor · Sep 2024

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Brian Halligan
From App to Suite to Platform, with HubSpot's Co-Founder Brian Halligan · Oct 2023

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Clem Delangue
Why the Future of Machine Learning is Open Source with Huggingface’s Clem Delangue · Feb 2023

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Dylan Field
Designing the Future: Dylan Field on AI, Collaboration, and Independence · Mar 2024

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Edwin Chen
The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen · Jul 2025

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Recent episodes

178 episodes from the feed, newest first.

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with Brian Armstrong

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Building an Autonomous Enterprise for Real-World Services with Netic Founder Melisa Tokmak
with Melisa Tokmak

Jul 2026
Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
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Jul 2026
Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel
with Glenn Fogel

Jul 2026
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
with Isaiah Taylor

Jul 2026
Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
with Noam Brown

Jun 2026
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
with Lip-Bu Tan

Jun 2026
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
with Mark Zuckerberg

Jun 2026
We Need An Ecosystem in AI, And Every Company Can Win A Place In It
Jun 2026
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
with Maxim Bar Kogan

May 2026
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
with Andrew Feldman

May 2026
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
with Jacob Helberg

May 2026
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
with Alexander Taubman

May 2026
Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
with Tuhin Srivastava

May 2026
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
with Philipp Herzig

Apr 2026
Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
with Bill McDermott

Apr 2026
The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
with Jeremy Allaire

Apr 2026
AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
with Liam Fedus

Apr 2026
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
with Andrej Karpathy

Mar 2026
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
with Simon Last

Mar 2026