Unsupervised Learning with Jacob Effron

We probe the sharpest minds in AI in search for the truth about what’s real today, what will be real in the future and what it all means for businesses and the world. If you’re a builder, researcher or investor navigating the AI world, this podcast will help you deconstruct and understand the most important breakthroughs and see a clearer picture of reality. Follow this show and consider enabling notifications to stay up to date on our latest episodes. Unsupervised Learning is a podcast by Redpoint Ventures, an early-stage venture capital fund that has invested in companies like Snowflake, Stripe, and Mistral. Hosted by Redpoint investor Jacob Effron alongside Patrick Chase, Jordan Segall and Erica Brescia.

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Every guest on Unsupervised Learning with Jacob Effron

89 guests, ranked by how many people never want them back.

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Illia Polosukhin
Ep 3: NEAR CEO Illia Polosukhin on the Origins of the Transformer Paper and The Overlap Between AI and Crypto · Mar 2023

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Joshua Meier
Ep 72: Co-Founder of Chai Discovery Joshua Meier on 99% Faster Drug Discovery, BioTech’s AlphaGo Moment, Building Photoshop for Molecules · Aug 2025

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Joshua Xu
Ep 45: Founder & CEO of HeyGen Josh Xu on TikTok’s GenAI Dilemma, Trust and Safety and the Path to Interactive Avatars · Oct 2024

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Matei Zaharia
Ep 2: Databricks CTO Matei Zaharia on scaling and orchestrating large language models · Mar 2023

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Percy Liang
Ep 44: Co-Founder of Together.AI Percy Liang on What’s Next in Research, Reaction to o1 and How AI will Change Simulation · Oct 2024

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Baris Gultekin
Ep 41: Head of AI at Snowflake Baris Gultekin on Why They Built Their Own LLM, Governance as a Moat, and the Most Common Enterprise Use-Cases · Aug 2024

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Buck Shlegeris
Ep 93: CEO of Redwood Research Buck Shlegeris on OpenAI/HuggingFace Revelations, Fixing AI Safety & Takeover Odds · Sep 2026

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Jack Rae

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Jonathan Frankle
Ep 47: Chief AI Scientist of Databricks Jonathan Frankle on Why New Model Architectures are Unlikely, When to Pre-Train or Fine Tune, and Hopes for Future AI Policy · Nov 2024

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Linus Lee
Ep 22: Notion AI Engineer Linus Lee: Behind the Scenes of Notion AI · Nov 2023

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Matt Welsh
Ep 4: Fixie.ai CEO Matt Welsh on How LLMs Will Change the Way We Work · Apr 2023

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Bob McGrew
Ep 51: Former Chief Research Officer of OpenAI Bob McGrew - What Comes Next for AI? · Dec 2024

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Karol Hausman
Ep 70: Karol Hausman and Danny Driess (Physical Intelligence) Unpack the Most Recent Breakthroughs & Path to Generalist Robots · Jul 2025

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Ari Morcos
AI Round Up: Ari Morcos from Datalogy AI and Rob Toews from Radical VC on Karpathy Reactions, OpenAI’s Dealmaking, & Bubble Reality Check · 2 episodes

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Jeremy Howard

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Jerry Liu
Ep 18: LlamaIndex CEO Jerry Liu on Trends in LLM Applications · Sep 2023

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Jurgen Schmidhuber
Ep 90: AI Pioneer Jürgen Schmidhuber on the State of AI Today · Jul 2026

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Michelle Pokrass
Ep 64: GPT 4.1 Lead at OpenAI Michelle Pokrass: RFT Launch, How OpenAI Improves Its Models & the State of AI Agents Today · May 2025

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Mike Conover
Ep 7: Co-Creator of Databricks Dolly Mike Conover on Open-Source LLMs · May 2023

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Thomas Larsen

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Tri Dao
Ep 74: Chief Scientist of Together.AI Tri Dao On The End of Nvidia's Dominance, Why Inference Costs Fell & The Next 10X in Speed · Sep 2025

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Clément Delangue
Ep 1: Hugging Face CEO Clem Delangue on The Future of Open vs Closed Source in AI · Feb 2023

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Alex Ratner
Ep 15: Snorkel AI CEO Alex Ratner on What's Needed for Wider-Spread Enterprise AI Adoption · Aug 2023

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Simon Hørup Eskildsen
Ep 71: CEO of TurboPuffer Simon Eskildsen on Building Smarter Retrieval, AI App Must-Have Features & Current State of Vector DBs · Jul 2025

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Tantum Collins
Ep 8: Ex-DeepMind/WhiteHouse Operator Tantum Collins on AI Regulation and Geopolitical Impacts · May 2023

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Aran Komatsuzaki
Ep 12: EleutherAI's Aran Komatsuzaki on Open-Source Models' Future and Thought Cloning · Jul 2023

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Dave Rogenmoser
Ep 6: Jasper CEO Dave Rogenmoser on the Future of Writing with AI · Apr 2023

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Jarek Kutylowski
Ep 46: CEO of DeepL Jarek Kutylowski on Specialized vs. General Models, Beating Google and a Future with Synchronous Translation · Oct 2024

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Peter Welinder
Ep 9: Open AI VP of Product Peter Welinder on OpenAI’s Strategy and AI’s Future · Jun 2023

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Vincent Vanhoucke
Ep 56: Distinguished Engineer at Waymo Vincent Vanhoucke Unpacks the Breakthroughs and Bottlenecks of Self-Driving · Feb 2025

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Alexandru Costin
Ep 16: VP of Generative AI at Adobe Alexandru Costin on The Future of Content Creation · Aug 2023

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Andriy Mulyar
Ep 17: Nomic AI Co-Founder Andriy Mulyar on "GPT-4-All", LLMs in Video Games, and Apple's AI Strategy · Sep 2023

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Bill Peebles
Ep 76: Sora Creators Bill Peebles, Rohan Sahai & Thomas Dimson on Their Unexpected Viral Success · Nov 2025

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Connor Zwick
Ep 40: CEO of Speak.com Connor Zwick on How AI Will Change the Way we Learn · Aug 2024

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Danny Driess

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Jeff Huber
Ep 14: Chroma CEO Jeff Huber on Vector Databases, Multimodal Embeddings & Building an AI Startup · Aug 2023

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Jordan Schneider
Ep 78: Jordan Schneider, Host of China Talk, on AI Race, Key Policy Decisions & Unpacking Geopolitical Chip Tension · Dec 2025

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Krish Ramineni
Ep 37: Co-Founder and CEO of Fireflies.ai Krish Ramineni on How AI Catalyzed Fireflies to 16M Users · Jul 2024

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Mike Schroepfer
Ep 57: Former CTO of Meta Mike Schroepfer on the Path to Powering the AI Revolution · Mar 2025

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Nicole Brichtova
Ep 75: Nano Banana’s Oliver Wang and Nicole Brichtova - Behind the Breakthrough as Gemini Tops the Charts · Sep 2025

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