No Priors

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

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Every guest on No Priors

150 guests, ranked by how many people never want them back.

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Isaiah Taylor
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor · Jul 2026

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Pushmeet Kohli
Meet AlphaEvolve: The Autonomous Agent That Discovers Algorithms Better Than Humans With Google DeepMind’s Pushmeet Kohli and Matej Balog · Jun 2025

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Sriram Krishnan
America’s Plan to Dominate the Full AI Stack with Sriram Krishnan · Jul 2025

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Jason Kelly
If DNA is Code, Can AI Help Write It? Scaling Cell Programming and Synthetic Biology, with Ginkgo Bioworks Co-founder and CEO Jason Kelly · Sep 2023

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Eric Steinberger
Building toward a bright post-AGI future with Eric Steinberger from Magic.dev · Aug 2024

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Harrison Chase
Open sourcing AI app development with Harrison Chase from LangChain · Mar 2024

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Jacob Helberg
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg · 2 episodes

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Mike Knoop
How the ARC Prize is democratizing the race to AGI with Mike Knoop from Zapier · Jun 2024

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Peter Chen
Building the factories of the future with Covariant CEO Peter Chen · Jan 2024

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Sajith Wickramasekara
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara · Nov 2025

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Stanley Tang

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Albert Gu

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Alex Graveley
What’s Beyond GitHub Copilot? With Copilot's Chief Architect and founder of Minion.AI Alex Graveley · Mar 2023

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Alex Rives

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Alexander Taubman
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman · May 2026

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Andy Fang
Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang · Jul 2026

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Ankur Goyal
Launching AI products with Braintrust’s CEO Ankur Goyal · Oct 2024

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Beyang Liu
Coding in Collaboration with AI with Sourcegraph CTO Beyang Liu · Jan 2024

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Bill McDermott
Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott · Apr 2026

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Brandon McKinzie

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CJ Desai
No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai · Jan 2026

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Chelsea Finn
The Robotics Revolution, with Physical Intelligence’s Cofounder Chelsea Finn · Mar 2025

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Cheng Chi

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Dan Hendrycks
National Security Strategy and AI Evals on the Eve of Superintelligence with Dan Hendrycks · Mar 2025

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Daniel Nadler
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler · Sep 2025

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Denis Yarats

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Devi Parikh
The Timeline for Realistic 4-D: Devi Parikh from Meta on Research Hurdles for Generative AI in Video and Multimodality · Jul 2023

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Edo Liberty
Improving search with RAG architecture with Pinecone CEO Edo Liberty · Feb 2024

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Emil Michael
AI and the Future of Warfare with US Under Secretary of War Emil Michael · Jan 2026

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Emily Glassberg Sands
Build AI products at on-AI companies with Emily Glassberg Sands from Stripe · Feb 2024

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Eric Mitchell
O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie · May 2025

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Eric Zelikman
Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman · Oct 2025

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Erik Bernhardsson
Erik Bernhardsson on Creating Tools That Make AI Feel Effortless · Jan 2025

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Gabe Pereyra
Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra · Dec 2025

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Glen Coates
The Copilot for Ecommerce with Shopify VP of Core Product Glen Coates · Jan 2024

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Gonen Stein

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Illia Polosukhin
The Intersection of AI and Blockchain, with Transformers author and NEAR founder Illia Polosukhin · Sep 2023

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Isa Fulford
Inside Deep Research with Isa Fulford: Building the Future of AI Agents · Apr 2025

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Jack Dent
Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier · Jul 2025

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Jakob Uszkoreit
AI-Powered Biological Software with Jakob Uszkoreit, CEO of Inceptive · Aug 2023

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Recent episodes

178 episodes from the feed, newest first.

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Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
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How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
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Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
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Jun 2026
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
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Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
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Jun 2026
We Need An Ecosystem in AI, And Every Company Can Win A Place In It
Jun 2026
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
with Maxim Bar Kogan

May 2026
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
with Andrew Feldman

May 2026
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
with Jacob Helberg

May 2026
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
with Alexander Taubman

May 2026
Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
with Tuhin Srivastava

May 2026
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
with Philipp Herzig

Apr 2026
Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
with Bill McDermott

Apr 2026
The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
with Jeremy Allaire

Apr 2026
AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
with Liam Fedus

Apr 2026
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
with Andrej Karpathy

Mar 2026
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
with Simon Last

Mar 2026