The a16z Show

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

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Every guest on The a16z Show

694 guests, ranked by how many people never want them back.

1. —
   Satish Talluri
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2. —
   Saurabh Ladha
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3. —
   Scott Clark
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4. —
   Seema Amble

   Big Ideas 2026: The Enterprise Orchestration Layer · Dec 2025

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5. —
   Shannon Schiltz

   Salary Transparency: Clarity or Chaos? · 2 episodes

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6. —
   Sharon Chang

   a16z Podcast: Earned Secrets · Aug 2018

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7. —
   Sherie James
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8. —
   Simon Denny

   The Art of Technology, The Technology of Art · Jul 2024

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9. —
   Simon Mo

   The Engine Powering Open-Source AI · Aug 2026

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10. —
    Sinead Bovell

    Beyond Avatars: How AI is Reshaping Online Identity · Apr 2023

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11. —
    Stefano Ermon

    Beyond Uncanny Valley: Breaking Down Sora · Feb 2024

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12. —
    Steijn Pelle

    AI for America's Small Businesses | Lassie · Jul 2026

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13. —
    Stephanie Zhang
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14. —
    Steve Zhao

    The Challenge of Replicating Reality · Feb 2023

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15. —
    Steven Sinofksy
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16. —
    Steven Snow
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17. —
    Stina Ehrensvärd
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18. —
    Sumit Shah
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19. —
    Susannah Fox

    a16z Podcast: Dark Data in Healthcare · Jan 2019

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20. —
    Ted Ullyot
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21. —
    Teresa Carlson

    a16z Podcast: The Cloud and The Public Sector · May 2016

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22. —
    Terry Angelos

    a16z Podcast: The Oral History Of TrialPay — Obstacles and Opportunities in Payments · May 2018

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23. —
    Terry Brown
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24. —
    Thomas Davenport

    a16z Podcast: Automation, Jobs, & the Future of Work (and Income) · May 2016

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25. —
    Thomas Rando

    a16z Podcast: The Science Of Extending Life · Apr 2017

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26. —
    Tiffany Zhong

    Designing for, Marketing to, and Partnering With Gen Z · Oct 2020

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27. —
    Tim Mayopoulos

    Inside the $13T Mortgage Machine · Sep 2025

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28. —
    Tina Bhatnagar

    a16z Podcast: Building Companies in Crypto, from People to Code · Jul 2018

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29. —
    Tom Hofmann

    All About Ransomware · Feb 2021

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30. —
    Tom Mitchell

    a16z Podcast: The History and Future of Machine Learning · Jun 2019

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31. —
    Tom Preston-Werner

    Turning Open Source Developers Into Superfans · Aug 2020

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32. —
    Tony Stoyanov
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33. —
    Travis Ferber

    Predicting Revenue in Usage-based Pricing · Jun 2024

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34. —
    Travis McPeak

    Cybersecurity's Past, Present, and AI-Driven Future · Jun 2024

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35. —
    Trevor Bedford

    Preventing Pandemics with Genomic Epidemiology · Jun 2020

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36. —
    Troy Kirwin
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37. —
    Turner Caldwell

    Energy, Minerals, and the Physical Stack Behind AI · 2 episodes

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38. —
    Usman Azam

    Building the First CAR T Company · Feb 2020

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39. —
    Vas Narasimhan

    On Pharma Trends and Big Company Innovation · 2 episodes

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40. —
    Vaughn Ferguson
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