The Human Upgrade

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Every guest on The Human Upgrade

842 guests, ranked by how many people never want them back.

1. —
   David Haussler

   Say GeNOme to Cancer with David Haussler · Sep 2016

   0 votes

   Never again
2. —
   David Hinds

   Hacking the ‘Middle-Age Spread’ – Interventions With Dave – David Hinds : 1038 · Apr 2023

   0 votes

   Never again
3. —
   David Liepert

   Covid-19 Turns Inflammation from Protective to Predatory – Dave Asprey with Dr. David Liepert : 690 · Apr 2020

   0 votes

   Never again
4. —
   David Nurse

   How to Fuel Your Follow-Through and Finally Reach Your Goals – David Nurse : 1046 · May 2023

   0 votes

   Never again
5. —
   David Oakley

   How Measuring Brain Function Leads to Performance Upgrades – David Oakley, Ph.D., with Dave Asprey : 867 · Oct 2021

   0 votes

   Never again
6. —
   David Osborn

   The Business of Building Wealth - David Osborn, Serial Entrepreneur : 490 · May 2018

   0 votes

   Never again
7. —
   David Steinman

   Protecting Our Children from Chemical Toxins - David Steinman : 1166 · May 2024

   0 votes

   Never again
8. —
   David Waknine

   David Waknine: Adversity, Filming A Documentary & Weight Loss - #209 · Apr 2015

   0 votes

   Never again
9. —
   Dawa Tarchin Phillips

   Living In The Present: Former Monk, Dawa Tarchin Phillips : 468 · Feb 2018

   0 votes

   Never again
10. —
    Dawson Church

    Mastering Brain Waves and Creating Mind Bridges – Dawson Church : 653 · 2 episodes

    0 votes

    Never again
11. —
    Dean Simonton

    Intelligence is Not Enough: The Genius Zone - Dean Simonton : 576 · Mar 2019

    0 votes

    Never again
12. —
    Deed Harrison
    0 votes

    Never again
13. —
    Deirdre Barrett

    Inspired Sleep - Putting Your Dreams to Work - Deirdre Barrett : 464 · Feb 2018

    0 votes

    Never again
14. —
    Diane Closser

    Hacking Weight Loss Resistance – Interventions With Dave – Diane Closser : 930 · Apr 2022

    0 votes

    Never again
15. —
    Divya Chander

    Consciousness, Drugs, & Brain Upgrades: Anesthesiologist Neuroscientist Divya Chander : 547 · Nov 2018

    0 votes

    Never again
16. —
    Dolce Conde

    Home Lab Testing 101: Your Guide to Great Results – Dolce Conde : 922 · Mar 2022

    0 votes

    Never again
17. —
    Dominic Denk

    Urolithin A: The Miracle Compound - Dr. Dominic Denk : 1119 · Dec 2023

    0 votes

    Never again
18. —
    Don Huber

    Why We Need to KO the GMO with Don Huber · Jun 2016

    0 votes

    Never again
19. —
    Don Wood

    How to Stay Present No Matter What – Don Wood, Ph.D. : 648 · Nov 2019

    0 votes

    Never again
20. —
    Donna Gates

    #122 Donna Gates on Body Ecology · May 2014

    0 votes

    Never again
21. —
    Dorian Greenow

    Get Your Mojo On With All Things Keto – Dorian Greenow with Dave Asprey : 824 · May 2021

    0 votes

    Never again
22. —
    Doug McGuff

    Body By Science - Dr. Doug McGuff, MD · 3 episodes

    0 votes

    Never again
23. —
    Drew Manning

    Empathy: the Unexpected Key to Transforming Lives, Drew Manning : 534 · Oct 2018

    0 votes

    Never again
24. —
    Dwight Jennings

    Dr. Dwight Jennings: A Live Look at Bite Realignment & How TMJ Impedes Performance #182 · 2 episodes

    0 votes

    Never again
25. —
    Edward Park

    Exosomes vs Stem Cells and LIFE-CHANGING Advice with Harvard Physician Dr. Edward Park : 1224 · Nov 2024

    0 votes

    Never again
26. —
    Eli Block

    Eli Block: OneTaste, Orgasmic Meditation & Flow State - #254 · Oct 2015

    0 votes

    Never again
27. —
    Elie Abirached

    The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489 · Jun 2026

    0 votes

    Never again
28. —
    Elisabeth Carson
    0 votes

    Never again
29. —
    Elizabeth Yurth

    Spermidine's Role in Cellular Health - Dr. Elizabeth Yurth : 1160 · 2 episodes

    0 votes

    Never again
30. —
    Elle Russ

    Solving the Hypothyroid Epidemic with Elle Russ · Oct 2016

    0 votes

    Never again
31. —
    Emily Deans

    #4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking) · Sep 2011

    0 votes

    Never again
32. —
    Emma Loewe

    8 Natural Landscapes That Will Restore Your Energy – Emma Loewe : 926 · Apr 2022

    0 votes

    Never again
33. —
    Eric Kandel

    The Unusual Brain of Dr. Eric Kandel : 538 · Oct 2018

    0 votes

    Never again
34. —
    Eric Langshur

    Be A Boss With Your Brain, Heart, & Gut - Eric Langshur : 457 · Jan 2018

    0 votes

    Never again
35. —
    Eric Merola
    0 votes

    Never again
36. —
    Erin Oprea

    Erin Oprea - Tabatas: Like Getting HIIT by a 4x4 - #313 · May 2016

    0 votes

    Never again
37. —
    Evan Brand

    Evan Brand: Forest Bathing, Repairing Your Vision & Adaptogens - #268 · Dec 2015

    0 votes

    Never again
38. —
    Fairfax Hackley

    Bodybuilders are the Original Biohackers - Fairfax Hackley : 558 · Jan 2019

    0 votes

    Never again
39. —
    Frank Shallenberger

    Ozone Therapy: Strengthen Your Immunity and Combat Viruses - Dave Asprey Talks with Dr. Frank Shallenberger : 691 · 2 episodes

    0 votes

    Never again
40. —
    Frank Zane

    Strength Training Upgrade: Transform Your Body & Mind - Frank Zane & Ben Pakulski : 1050 · May 2023

    0 votes

    Never again