The Human Upgrade

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Every guest on The Human Upgrade

842 guests, ranked by how many people never want them back.

1. —
   Amy Webb

   Synthetic Biology to Become a Major Economic Driver, Part 2 – Amy Webb : 914 · Mar 2022

   0 votes

   Never again
2. —
   Mary Claire Haver

   Menopause: What to Know, What to Ask & What to Do – Mary Claire Haver, M.D. : 1015 · Jan 2023

   0 votes

   Never again
3. —
   Vivek Murthy

   3 Simple Tools That Banish Loneliness and Strengthen Connection – Dr. Vivek Murthy with Dave Asprey : 756 · Nov 2020

   0 votes

   Never again
4. —
   Gabor Maté

   Don’t Accept Suffering as Normal – Dr. Gabor Maté : 977 · Sep 2022

   0 votes

   Never again
5. —
   Gretchen Rubin

   Habits, Happiness and Human Nature – Gretchen Rubin : 636 · Oct 2019

   0 votes

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6. —
   Jay Shetty

   How to Think Like a Monk – Jay Shetty with Dave Asprey : 739 · Sep 2020

   0 votes

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7. —
   Chris Palmer

   How Your Mitochondria Control Your Brain Energy – Chris Palmer, M.D. : 1012 · Jan 2023

   0 votes

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8. —
   A.J. Jacobs

   #112 AJ Jacobs on His Life as an Experiment · Apr 2014

   0 votes

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9. —
   Amishi Jha

   How Focus and Attention Powers Your Mind – Amishi Jha, Ph.D. : 940 · May 2022

   0 votes

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10. —
    Randy Jackson

    From Food Divorce to Emotional Overhaul: Randy Jackson’s Health Journey : 734 · Aug 2020

    0 votes

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11. —
    Susan David

    How to Build Your Emotional Agility and Resilience – Susan David, Ph.D. & Joan Rosenberg, Ph.D. : 887 · 2 episodes

    0 votes

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12. —
    Nadia Bolz-Weber

    Finding Pleasure in Fasting, Sex and Spirituality – Nadia Bolz-Weber with Dave Asprey : 785 · Jan 2021

    0 votes

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13. —
    Blake Griffin

    Thriving Under Pressure with NBA Star Blake Griffin : 667 · Feb 2020

    0 votes

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14. —
    BJ Fogg

    How to Build New Habits and KEEP Them! BJ Fogg & James Clear : 1256 · 3 episodes

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15. —
    Josh Duhamel

    Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537 · Sep 2026

    0 votes

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16. —
    Aron D'Souza

    Steroids, Gene Therapy, Peptides: The Future of ENHANCED Sports with Aron D’Souza : 1215 · Oct 2024

    0 votes

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17. —
    Robert McKee

    Robert Mckee: Master the Art of Storytelling - #232 · Jul 2015

    0 votes

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18. —
    Adam Gazzaley

    Game-Changing Focus: Play the World’s First FDA-Approved Video Game – Dr. Adam Gazzaley : 1089 · Sep 2023

    0 votes

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19. —
    Arianna Huffington

    The Good Life: Peace, Strength and Wisdom – Arianna Huffington : 600 · 3 episodes

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20. —
    Dan Harris

    Mind, Buddha, Spirit with Dan Harris · Sep 2016

    0 votes

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21. —
    Gabrielle Bernstein

    6 Messages to Get You Through Tough Times by Spiritual Entrepreneur Gabrielle Bernstein : 747 · 2 episodes

    0 votes

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22. —
    Gary Brecka

    Gary Brecka: The SECRET Blood Marker That Could Save Your Life! (pt. 2) : 1248 · 2 episodes

    0 votes

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23. —
    Gary Taubes

    Bad Science and Diet Lies Keep Feeding Obesity: Gary Taubes with Dave Asprey : 778 · 2 episodes

    0 votes

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24. —
    John Gray

    The Real Reason She Loses Interest in Sex | John Gray : 1465 · 5 episodes

    0 votes

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25. —
    Lisa Bilyeu

    Lisa Bilyeu: How to hack confidence : 1331 · 2 episodes

    0 votes

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26. —
    Mona Sharma

    Ayurveda Meets Biohacking: 5000-Year-Old Medicine Secrets for Modern Stress | Mona Sharma : 1284 · May 2025

    0 votes

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27. —
    Olga Khazan

    Identity Hacker: How to Completely Change Your Personality at ANY Age | Olga Khazan : 1268 · Apr 2025

    0 votes

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28. —
    Wim Hof

    3 Pillars of Performance: Cold, Breath & Mind – Wim Hof with Dave Asprey : 750 · 2 episodes

    0 votes

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29. —
    Dan Siegel

    Interpersonal Neurobiology: A Systems-Thinking Approach to Optimal Health – Dr. Dan Siegel : 587 · Apr 2019

    0 votes

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30. —
    Daryl Davis

    How to HACK Your HATE with Daryl Davis (The Jazz Musician Who Defeated the KKK) : 1234 · Dec 2024

    0 votes

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31. —
    Deepak Chopra

    Spirituality Upgrade: Exploring Energy, Experience & Reality – Deepak Chopra & Abdul Holdijk : 953 · 2 episodes

    0 votes

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32. —
    Mark Hyman

    What it takes to be “Young Forever!” | Mark Hyman : 1385 · 9 episodes

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33. —
    Matthew Modine

    Upgrading Our Collective Consciousness – Matthew Modine : 620 · Aug 2019

    0 votes

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34. —
    Patrick Schwarzenegger

    How to Build a Better Brain, Brand & Business! – Patrick Schwarzenegger · 2 episodes

    0 votes

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35. —
    Renee Fleming

    How to Use Music to Heal Your Mind and Body with Renée Fleming : 1185 · Jul 2024

    0 votes

    Never again
36. —
    William Davis

    How The Health Care System Wants To Keeps You Sick & What You Can Do To Change It! – Dr. William Davis · 2 episodes

    0 votes

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37. —
    Amanda Kloots

    How to Live Your Life After Great Loss – Amanda Kloots with Dave Asprey : 837 · Jul 2021

    0 votes

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38. —
    Casey Means

    Good Energy: Transformative Metabolic Health Tips - Dr. Casey Means : 1167 · 2 episodes

    0 votes

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39. —
    Chip Conley

    How to Navigate Mid-life Transitions as a Modern Elder – Chip Conley, MBA : 1045 · Apr 2023

    0 votes

    Never again
40. —
    Danica Patrick

    Exploring Human Potential, Sciencing Spirituality, and Getting Intense – Danica Patrick Interviews Dave Asprey : 1019 · 2 episodes

    0 votes

    Never again