The Human Upgrade

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Every guest on The Human Upgrade

842 guests, ranked by how many people never want them back.

1. —
   Elissa Epel

   Age Backwards by Hacking Your Telomeres with Stress - Dr. Elissa Epel - #436 · Oct 2017

   0 votes

   Never again
2. —
   Jake Knapp

   Solving Huge Problems In Less Time w/ Jake Knapp · Nov 2016

   0 votes

   Never again
3. —
   Jerry Colonna

   Becoming Buddha: How to Be Happy – Jerry Colonna : 1157 · May 2024

   0 votes

   Never again
4. —
   Jesse Itzler

   How to Relentlessly Prioritize Your Life – Jesse Itzler : 1121 · Jan 2024

   0 votes

   Never again
5. —
   Julie Holland

   Psychedelics Offer New Solutions for Social Isolation – Dr. Julie Holland with Dave Asprey : 757 · 2 episodes

   0 votes

   Never again
6. —
   Martin Picard

   Understanding the Behaviour of Mitochondria - Martin Picard : 565 · Feb 2019

   0 votes

   Never again
7. —
   Matteo Franceschetti

   How Sleep Tech Improves Your Performance – Matteo Franceschetti : 997 · 2 episodes

   0 votes

   Never again
8. —
   Michael Platt

   Curb Your Adrenaline, Improve Your Health – Dr. Michael Platt : 610 · Jul 2019

   0 votes

   Never again
9. —
   Michael Scott Moore

   Finding Gratitude in Captivity: Michael Scott Moore : 530 · Sep 2018

   0 votes

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10. —
    Robert Lustig

    Upgrade Your Metabolic System with the Right Foods – Dr. Robert Lustig – Best of 2021 · 2 episodes

    0 votes

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11. —
    Rohan Oza

    This is Shark Tank not Goldfish Tank: Rohan Oza : 549 · Dec 2018

    0 votes

    Never again
12. —
    Ryan Smith

    Toss the Candles! Biological Age Is Your New Birthday – Ryan Smith : 883 · Dec 2021

    0 votes

    Never again
13. —
    Sara Gottfried

    #108 Dr. Sara Gottfried – The Hormone Cure · 2 episodes

    0 votes

    Never again
14. —
    Satchin Panda

    SLEEP: Circadian Rhythm to the Rescue: A Top 10 Episode with Satchin Panda · 4 episodes

    0 votes

    Never again
15. —
    Steven Greer

    Steven Greer | UAP’s and Remote Viewing Techniques for Non-Human Life : 1517 · Aug 2026

    0 votes

    Never again
16. —
    Tim Chang

    There’s So Much ‘Wow’ in Every Moment – Tim Chang : 598 · Jun 2019

    0 votes

    Never again
17. —
    Aditi Nerurkar

    Biohacking Stress & Burnout – Dr. Aditi Nerurkar : 1153 · Apr 2024

    0 votes

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18. —
    Alan Bauman

    Hacking Hair Follicle Function – Dr. Alan Bauman and Dr. Sophia Kogan : 844 · 2 episodes

    0 votes

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19. —
    Alan Goldhamer

    What’s Up with Water Fasting? – Dr. Alan Goldhamer with Dave Asprey : 780 · Jan 2021

    0 votes

    Never again
20. —
    Alex Tatem

    I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem : 1509 · Jul 2026

    0 votes

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21. —
    Amy Shah

    Why You Get Hungry, How Gut Bacteria Matters & the Perils of Food Industry Manipulation – Amy Shah, M.D. : 1029 · 4 episodes

    0 votes

    Never again
22. —
    Andrew Weil

    Sync Your Body & Mind for a More Vibrant Life – Legacy Upgrade ft. Dr. Andrew Weil : 1008 · 2 episodes

    0 votes

    Never again
23. —
    Ben Patrick

    Knees Over Toes: Fix Knees, Calves, Shins & Shoulders – Ben Patrick : 1127 · Jan 2024

    0 votes

    Never again
24. —
    Benjamin Bikman

    Fix Your Blood Sugar: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Benjamin Bikman : 1252 · Feb 2025

    0 votes

    Never again
25. —
    Bill Harris

    Bill Harris: Hacking Meditation with Holosync - #186 · Jan 2015

    0 votes

    Never again
26. —
    Billy Carson

    Ancient Secrets THEY Hid from You (That Still Work Today!) – Lost Technology, The Pyramid Code, and Quantum Reality | Billy Carson (Harvard & MIT) & Elisabeth Carson : 1246 · Jan 2025

    0 votes

    Never again
27. —
    Brendon Burchard

    Create the Person You Want To Be - Brendon Burchard : 557 · 3 episodes

    0 votes

    Never again
28. —
    Byron Katie

    Control Your Mindset with 4 Questions – Legacy Upgrade ft. Byron Katie : 965 · 2 episodes

    0 votes

    Never again
29. —
    Caroline Leaf

    Raise Resilient Minds: How to Help Your Kids Self Regulate & Form Better Habits - Dr. Caroline Leaf : 1078 · 2 episodes

    0 votes

    Never again
30. —
    Cassandra Quave

    Finding Modern Medicines in the Botanical World – Cassandra Quave, Ph.D. : 986 · Oct 2022

    0 votes

    Never again
31. —
    Charles Poliquin

    Special Edition: Aerobic exercise may be destroying your body - Charles Poliquin : 537 · 2 episodes

    0 votes

    Never again
32. —
    Chris Masterjohn

    Unlocking Health Through Your Genetic Code: Healing from Veganism, Chronic Pain & Stressors - Chris Masterjohn : 1090 · 2 episodes

    0 votes

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33. —
    Dan Buettner

    How Long Can Humans Really Live… (with Dan Buettner) : 1393 · 2 episodes

    0 votes

    Never again
34. —
    Darin Olien

    The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293 · Jun 2025

    0 votes

    Never again
35. —
    David Perlmutter

    The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498 · 7 episodes

    0 votes

    Never again
36. —
    David Rabin

    BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486 · 5 episodes

    0 votes

    Never again
37. —
    Daymond John

    How Overcoming a Health Scare and Embracing Biohacking Led to New Purpose and Vitality - Daymond John : 1170 · 2 episodes

    0 votes

    Never again
38. —
    Dennis McKenna

    Adventures in Ayahuasca & Psychedelic Medicine with Dennis McKenna · Jul 2016

    0 votes

    Never again
39. —
    Dominic D'Agostino

    Keying in on Ketones with Dominic D'Agostino · 3 episodes

    0 votes

    Never again
40. —
    Doug Bopst

    How Fitness Saved a Life and Became a Livelihood – Doug Bopst with Dave Asprey : 806 · Mar 2021

    0 votes

    Never again