Into the Impossible With Brian Keating

Think like a physicist. Wonder like a human. Into the Impossible is where Cosmic Conversations happen — uniting Nobel Prize winners, iconoclasts, authors, and technologists to explore reality’s deepest questions. From AI to aliens, from biophysics to the brain, from the cosmos to the multiverse, Brian Keating, Chancellor’s Distinguished Professor of Physics at UC San Diego covers it all. If you’ve ever asked What’s out there? or What’s next?, this is where curiosity meets clarity. Learn to think like this. 🎙 Full episodes, notes & more: briankeating.com/podcast

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Every guest on Into the Impossible With Brian Keating

334 guests, ranked by how many people never want them back.

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Niall Ferguson
Niall Ferguson: DOOM! (#273) · Nov 2022

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Jaron Lanier
VR Will Expand Human Consciousness. Jaron Lanier - #531 · Nov 2025

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Barry Barish
Exploring Curiosity With Nobel Prize Winner Barry Barish (#374) · 4 episodes

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Cumrun Vafa
Cumrun Vafa: Puzzles to Unravel the Universe (2020) · 3 episodes

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Konstantin Batygin
Evidence for Planet 9? A conversations with Caltech Professor Konstantin Batygin! (#137) · Apr 2021

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Bret Weinstein
The Next Phase of Human Evolution - Bret Weinstein - #532 · 2 episodes

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Frank Wilczek
Nobel Prize Winner Frank Wilczek: Fundamentals — What Are The 10 Keys To Reality? (#109) · 2 episodes

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Eric Weinstein
Eric Weinstein “You’re being lied to!” with Avi Loeb [Ep. 482] · 24 episodes

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Avi Loeb
Did We Find Alien Technology? Avi Loeb Explains - #545 · 17 episodes

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Sara Seager
MIT Professor Sara Seager: Love, Loss, & Life in the Cosmos (#144) · 2 episodes

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Harry Cliff
How Strange Anomalies Lead to World-Changing Discoveries with Harry Cliff · 2 episodes

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Richard Dawkins
Richard Dawkins: The God Delusion: Atheism & AI · 3 episodes

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Roger Penrose
Sir Roger Penrose Faith, Fantasy, and the Big Questions in Modern Physics (#324) · 6 episodes

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Nick Bostrom
Are We Living in a Simulation? Nick Bostrom (2022) · 3 episodes

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Lee Smolin
Lee Smolin: String Theory is Still Wrong (#152) · May 2021

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Ann Druyan
The Many Worlds of Ann Druyan: Matriarch of the Cosmos (#055) · Jul 2020

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Ryan Holiday
Ryan Holiday | Courage Is Calling: Fortune Favors the Brave! @Daily Stoic (#190) · Oct 2021

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Piers Morgan
You're full of SHIT! Piers Morgan & Brian Keating take down Moon Landing Denier · Apr 2026

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Mo Gawdat
Mo Gawdat: “Life is a Video Game!” | The Shocking Case for Intelligent Design (#389) · Jan 2024

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Robert Sapolsky
Why There’s No Such Thing as Free Will w/ Robert Sapolsky (#395) · Feb 2024

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Gad Saad
Gad Saad: How to Stay Resilient and Happy After the October 7 Massacre (#378) · 2 episodes

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Bill Perkins
Bill Perkins: Winners DIE WITH ZERO! (#098) · Nov 2020

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Peter Diamandis
Godlike AI Is Here! Peter Diamandis Debates Brian Keating - #557 · 4 episodes

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Becky Smethurst
YouTube’s #1 Astronomer Dr. Becky Smethurst: “Don’t Dumb It Down!” (#069) · Sep 2020

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Sabine Hossenfelder
Do We Have Free Will and Will AI Have It Too? Sabine Hossenfelder - #507 · 6 episodes

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Steven Pinker
Steven Pinker on Cancel Culture, Common Knowledge & AI - #518 · 2 episodes

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Carl Zimmer
Life's Edge: Exploring the Boundary between Living & Nonliving | Carl Zimmer | Into the Impossible (#320) · Jun 2023

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Michael Knowles
Michael Knowles: Speechless (#160) · Jun 2021

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Michio Kaku
Michio Kaku Went Viral On Diary of a CEO; I Had To Fact-Check · 4 episodes

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Steven Kotler
Steven Kotler: Master Your Flow with The Art of the Impossible (#165) · Jul 2021

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Dave Rubin
Brian Keating & Dave Rubin — DON’T BURN THIS BOOK: using free speech to avoid a Sci Fi dystopia (#042) · May 2020

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James Altucher
Brian Keating on the Israel-Gaza Conflict, Campus Politics & Podcasting w/ James Altucher · 13 episodes

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Kamal Ravikant
Kamal Ravikant: Love Yourself Like Your Life Depends On It! (#138) · Apr 2021

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David Perell
I Write Therefore I Am: David Perell— Building A Second Brain + Write of Passage (#139) · Apr 2021

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Mario Livio
Is Earth Unique? Mario Livio and Jack Szostak on the Odds of Alien Life [Ep. 457] · 2 episodes

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Tiffany Shlain
Author, Filmmaker Tiffany Shlain discusses her films, book 24/6, and the human side of tech (#047) · May 2020

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Eric Topol
Eric Topol: AI Doctors, Medicine's Future, and The Delta Variant (#173) · Aug 2021

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Jud Brewer
Dr. Jud Brewer : Fear, Freedom, and his book The Craving Mind (#049) · Jun 2020

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David Deutsch
David Deutsch Says We Will Build Humans Before We Build AGI - #515 · 2 episodes

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Ashlee Vance
Ashlee Vance Shares Crazy Stories from Elon Musk to the Billionaire Space Race (#348) · Sep 2023

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