The Human Upgrade

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Every guest on The Human Upgrade

842 guests, ranked by how many people never want them back.

1. —
   Paul Stamets

   Eat THESE Anti-Aging Mushrooms to Live Longer (Paul Stamets) : 1327 · 3 episodes

   0 votes

   Never again
2. —
   Payal Kadakia

   Goal Get It! How to Reflect, Dream and Focus Your Way to Success – Payal Kadakia : 911 · Mar 2022

   0 votes

   Never again
3. —
   Pooja Lakshmin

   #60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin · Sep 2013

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4. —
   Rachel Hollis

   What To Do About Things You Didn’t See Coming – Rachel Hollis with Dave Asprey : 763 · Nov 2020

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5. —
   Robert Cialdini

   7 Ways to Influence People – Robert Cialdini, Ph.D., with Dave Asprey : 821 · 2 episodes

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6. —
   Robynne Chutkan

   Battling Pathogens and Building Immunity Begins In Your Gut – Dr. Robynne Chutkan : 998 · Nov 2022

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7. —
   Rocco DiSpirito

   Rocco Dispirito: Cook Your Butt Off - #204 · Mar 2015

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8. —
   Scott Harrison

   Be The Anti-Mr. Smithers: How To Make Money To Give Away - Scott Harrison #445 : 445 · Nov 2017

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9. —
   Scott Lyons

   Too Much Crisis, Chaos & Stress in Your Life? How to Overcome Drama Addiction – Dr. Scott Lyons : 1047 · May 2023

   0 votes

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10. —
    Sergey Young

    3 Dimensions of Longevity That Will Extend Your Life – Sergey Young with Dave Asprey : 852 · 2 episodes

    0 votes

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11. —
    Stanislav Grof

    The Birth of LSD with Dr. Stanislav Grof, Father of Transpersonal Psychology - #428 · Sep 2017

    0 votes

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12. —
    Stephen Cave

    Death, Legacy & the Philosophy of Longevity — with Stephen Cave : 1297 · Jul 2025

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13. —
    Steven Gundry

    Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270 · 9 episodes

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14. —
    Susan Bratton

    The Science of Sex: Longevity, Pleasure & Performance - Susan Bratton : 1087 · Sep 2023

    0 votes

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15. —
    Tana Amen

    Why You Have to Heal Your Trauma to Free Your Energy – Tana Amen with Dave Asprey : 800 · Mar 2021

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16. —
    Tom Bilyeu

    How to Have Impact with Tom Bilyeu, Billion-Dollar Brand Builder - #430 · Sep 2017

    0 votes

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17. —
    Valter Longo

    How Fasting Resets Your Biology and Helps You Live Longer – Valter Longo, Ph.D., with Dave Asprey : 812 · Apr 2021

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18. —
    Vishen Lakhiani

    Meditation Hacks Get You Into A Peak State in Less Time – Vishen Lakhiani : 979 · 2 episodes

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19. —
    Walter O'Brien

    IQ vs. EQ With "Scorpion," Walter O'Brien : 469 · Feb 2018

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20. —
    Will Cole

    Heal the Relationship Between Your Food & Your Mood - Dr. Will Cole : 1033 · 2 episodes

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21. —
    William Li

    The Foods That Starve Cancer | William Li : 1481 · 3 episodes

    0 votes

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22. —
    Zach Bush

    Conscious Bacteria? The Secret New Science of Cellular Intelligence | Zach Bush : 1275 · 2 episodes

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23. —
    David Ludwig

    Fighting the Child Obesity Crisis - Dr. David Ludwig #375 · 2 episodes

    0 votes

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24. —
    David Meltzer

    Plug in to Your Own Power Source – David Meltzer : 631 · Oct 2019

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25. —
    Greg Wells

    Guided Breathing, Gamma Brainwaves and Going Beyond Flow State – Dr. Greg Wells with Dave Asprey : 721 · Jul 2020

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26. —
    Paul Saladino

    Is Red Meat the Fountain of Youth? Paul Saladino : 1229 · 4 episodes

    0 votes

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27. —
    Rachel Yehuda

    How Trauma Travels Through Generations and Changes Your Genes – Rachel Yehuda, Ph.D., with Dave Asprey : 769 · Dec 2020

    0 votes

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28. —
    Anthony Youn

    The Expert In Your Face: Youthful Skin Without Surgery – Dr. Anthony Youn : 1120 · Jan 2024

    0 votes

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29. —
    Cate Shanahan

    Why Seed Oils Are the Worst Foods in Your Diet & How To Avoid Them - Dr. Cate Shanahan : 1168 · 4 episodes

    0 votes

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30. —
    Cynthia Thurlow

    How Beef Is Destroying Your Hormones – Cynthia Thurlow : 1457 · 3 episodes

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31. —
    Dale Bredesen

    You Can Prevent and Even Reverse Cognitive Decline – Dr. Dale Bredesen with Dave Asprey : 754 · 2 episodes

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32. —
    Greg Kelly

    Fix What’s Making You Feel Old—From Joints to Mitochondria | Dr. Greg Kelly : 1296 · Jun 2025

    0 votes

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33. —
    James Fitzgerald

    Podcast #6: Optimum Performance Training with James Fitzgerald · Sep 2011

    0 votes

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34. —
    Lara Logan

    ‘Fast This Way’ to Take on the World – Dave Asprey Interviewed by Lara Logan : 782 · 2 episodes

    0 votes

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35. —
    Amber Lyon

    Amber Lyon on Psychedelic Healing & Reset.me – Podcast #143 · Aug 2014

    0 votes

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36. —
    Aubrey de Grey

    Diving into the Fountain of Youth with Aubrey de Grey · Jul 2016

    0 votes

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37. —
    Bruce Lipton

    The World is Your Petri Dish with Bruce Lipton · Aug 2016

    0 votes

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38. —
    Chris Bell
    0 votes

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39. —
    Chris Kresser

    #86 Your Personal Paleo Code with Chris Kresser · 2 episodes

    0 votes

    Never again
40. —
    Christopher Ryan

    #52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast · Jul 2013

    0 votes

    Never again