The Human Upgrade

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Every guest on The Human Upgrade

842 guests, ranked by how many people never want them back.

1. —
   Peter Osborne

   No Grain, No Pain: Why Removing Gluten is Key to Improving Your Health – Dr. Peter Osborne : 1140 · Mar 2024

   0 votes

   Never again
2. —
   Ramon Hervey II

   Prioritize Performance, Not Fame - Ramon Hervey II : 1150 · Apr 2024

   0 votes

   Never again
3. —
   Sal Di Stefano

   What You’re Getting Wrong About Exercise – Sal Di Stefano : 1134 · Feb 2024

   0 votes

   Never again
4. —
   Sean Stephenson

   How To Get Over Your Addiction To Pity - Dr. Sean Stephenson : 500 · Jun 2018

   0 votes

   Never again
5. —
   Shaun T

   Shaun T of Insanity: The Superpower of Selfishness - #443 · Nov 2017

   0 votes

   Never again
6. —
   Yuri Elkaim

   Yuri Elkaim: Adrenal Function, Neural Fine Tuning & Training - #212 · 2 episodes

   0 votes

   Never again
7. —
   Charles Brenner

   How To Boost NAD, The Coenzyme of Life: Charles Brenner : 491 · May 2018

   0 votes

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8. —
   Jordan Rubin

   #47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin · Jun 2013

   0 votes

   Never again
9. —
   Maria Menounos

   The Power of Perseverance - Maria Menounos : 1147 · Mar 2024

   0 votes

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10. —
    Mark Mattson

    Bonus: Intermittent Fasting Boosts Brain Power: Mark Mattson, Ph.D., with Dave Asprey · 2 episodes

    0 votes

    Never again
11. —
    Morgan Levine

    How to Slow Down Your Biological Aging – Morgan Levine, Ph.D. : 941 · May 2022

    0 votes

    Never again
12. —
    Nick Norwitz

    Stop Counting Calories! Diet Myths Exposed (And What to Do Instead) | Dr. Nick Norwitz : 1245 · Jan 2025

    0 votes

    Never again
13. —
    Terry Wahls

    Dr. Terry Wahls on Mitochondria, Health & Vegetables - Bulletproof Radio · 4 episodes

    0 votes

    Never again
14. —
    Alberto Villoldo

    Ayahuasca: How to Turn on Your Entire Brain at Once - Dr. Alberto Villoldo : 502 · 4 episodes

    0 votes

    Never again
15. —
    Andrew Salzman

    Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474 · 2 episodes

    0 votes

    Never again
16. —
    Anurag Singh

    Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277 · 4 episodes

    0 votes

    Never again
17. —
    Autumn Smith

    Meat Myths: Truth, Lies and Flawed Science – Autumn Smith : 950 · Jun 2022

    0 votes

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18. —
    Bob Hariri

    100 Years Old is the New 60 - Dr. Bob Hariri : 539 · Oct 2018

    0 votes

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19. —
    Dan Kittredge

    Dan Kittredge - Meanwhile, Back at the Ranch · May 2016

    0 votes

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20. —
    David Roberts

    How Much LONGER Will You Live By Eating Sulforaphane? David Roberts & John Gildea : 1175 · Jun 2024

    0 votes

    Never again
21. —
    Emily Fletcher

    Adult Talk: How to Get Your Kids to Meditate – Emily Fletcher with Dave Asprey : 817 · 3 episodes

    0 votes

    Never again
22. —
    Emily Willingham

    SEXUAL ENERGY SERIES-3: The Shock & Awe of Penis Evolution – Emily Willingham, Ph.D. : 789 · Feb 2021

    0 votes

    Never again
23. —
    Izabella Wentz

    A Guide to Strengthening & Healing Your Adrenals – Izabella Wentz, PharmD. : 1042 · 6 episodes

    0 votes

    Never again
24. —
    Joel Warsh

    The TRUTH About Vaccines for Kids (A Pediatrician Speaks Out on the Risks) | Joel "Gator" Warsh : 1238 · Jan 2025

    0 votes

    Never again
25. —
    Josh Axe

    Should You Eat Dirt? The “Healthy” Foods Destroying Your Gut – Dr. Josh Axe : 1289 · Jun 2025

    0 votes

    Never again
26. —
    Kara Fitzgerald

    Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald : 1461 · May 2026

    0 votes

    Never again
27. —
    Majid Fotuhi

    Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi : 1482 · Jun 2026

    0 votes

    Never again
28. —
    Marc David

    #114 Marc David Hacks into the Psychology of Eating · Apr 2014

    0 votes

    Never again
29. —
    Matt Cook

    Matt Cook: Everything You Need To Know About Stem Cells : 512 · Jul 2018

    0 votes

    Never again
30. —
    Pedram Shojai

    Energy Economics: Your Focus is Your Money Flow – Pedram Shojai with Dave Asprey : 758 · 5 episodes

    0 votes

    Never again
31. —
    Radha Agrawal

    Finding Joy, Building Community and Raising Your Own Pork – Radha Agrawal : 874 · Nov 2021

    0 votes

    Never again
32. —
    Ricki Lake

    What Medical Cannabis Can Do - Ricki Lake & Abby Epstein : 564 · Feb 2019

    0 votes

    Never again
33. —
    Sharon Hausman-Cohen

    Your Genes AREN’T Your Fate—The NEW Science of DNA Biohacking for SuperHuman Health | Sharon Hausman-Cohen : 1257 · Mar 2025

    0 votes

    Never again
34. —
    Stephanie Seneff

    Dr. Stephanie Seneff: Glyphosate Toxicity, Lowering Cholesterol & Getting Off Statins - #238 · Jul 2015

    0 votes

    Never again
35. —
    Stephanie Venn-Watson

    Scientists Just Discovered the Essential Nutrient That DOUBLES Dolphin Lifespan—But Should YOU Take It? | Stephanie Venn-Watson : 1256 · Mar 2025

    0 votes

    Never again
36. —
    Steve Omohundro

    Steve Omohundro Talks Technology for a Better World – Podcast #134 · Jul 2014

    0 votes

    Never again
37. —
    Abby Epstein
    0 votes

    Never again
38. —
    Abdul Hayy L. Holdijk

    Who Am I? Finding Spirituality by Disrupting Tradition with Abdul Hayy L. Holdijk : 710 · Jun 2020

    0 votes

    Never again
39. —
    Abdul Holdijk
    0 votes

    Never again
40. —
    Abelard Lindsay

    #82 CILTEP Revealed with Abelard Lindsay · Dec 2013

    0 votes

    Never again