The Human Upgrade

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Every guest on The Human Upgrade

842 guests, ranked by how many people never want them back.

1. —
   Graham Hancock

   Graham Hancock: Visionary Plants, DNA and Human History - #278 · Jan 2016

   0 votes

   Never again
2. —
   Andrew Huberman

   Dr. Andrew Huberman: Neuroscience Hacks for Peak Brain Performance and Stress Mastery : 1208 · 2 episodes

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   Never again
3. —
   Charan Ranganath

   The Science Behind Memory - Dr. Charan Ranganath : 1152 · Apr 2024

   0 votes

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4. —
   Kimbal Musk

   From Tech to Table: Kimbal Musk's Culinary Revolution : 1125 · 2 episodes

   0 votes

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5. —
   Steve Aoki

   Grinding it Out, Finding Center and Heading Toward a Neon Future – Steve Aoki : 666 · Feb 2020

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6. —
   Colleen Cutcliffe

   Hack Your Hunger: The Power of GLP-1 Probiotics - Colleen Cutcliffe, Ph.D. : 1151 · 5 episodes

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7. —
   David Sinclair

   How Harvard Researcher David Sinclair (and Dave Asprey) Manage COVID-19 Risk : 681 · 2 episodes

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8. —
   Stephen Porges

   The Nervous System Circuitry of Safety, Sound and Gratitude – Stephen Porges : 573 · 2 episodes

   0 votes

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9. —
   David Epstein

   David Epstein on the Sports Gene & the Science of Extraordinary Performance – #153 · Sep 2014

   0 votes

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10. —
    Arthur Brooks

    Arthur Brooks | Why Your Life Has No Meaning : 1438 · 2 episodes

    0 votes

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11. —
    Nir Eyal

    Nir Eyal: Addictive Tech, Killing Bad Habits & Apps for Life Hacking - #260 · Nov 2015

    0 votes

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12. —
    Bryan Johnson

    Don’t Die with Bryan Johnson : 1211 · 2 episodes

    0 votes

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13. —
    Sri Sri Ravi Shankar

    The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523 · 2 episodes

    0 votes

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14. —
    Peter McCullough

    Peter McCullough: Spike Protein Detected 3.6 Years After the Shot (Detox Protocol) : 1501 · Jul 2026

    0 votes

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15. —
    Tim Ferriss

    Tim Ferriss: Smart Drugs, Insect Protein, Sex, and His 3 Top Tips for a SUCCESSFUL Life : 1220 · 6 episodes

    0 votes

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16. —
    James Clear

    Use Atomic Habits to Upgrade Your Decisions – James Clear : 645 · Nov 2019

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17. —
    Susan Cain

    Discover Your Capacity to Create, Connect & Love – Susan Cain : 952 · Jun 2022

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18. —
    Rick Rubin

    Rick Rubin: How to Hack Your Mind for Creative Breakthroughs : 1251 · 2 episodes

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19. —
    John Abramson

    How Big Pharma Corrupts Medical Knowledge – Dr. John Abramson : 901 · Feb 2022

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20. —
    Philip Goff

    Redefine Your Reality & Unveil the Secrets of Your Conscious Mind - Philip Goff & Anil Seth : 1052 · 2 episodes

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21. —
    Brian Keating

    Merchants of Truth and Light: Losing the Nobel Prize - Brian Keating : 581 · Apr 2019

    0 votes

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22. —
    Jamie Metzl

    How Virus Resistance Can Help You Live to 100 – Jamie Metzl : 684 · Apr 2020

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23. —
    Rick Doblin

    Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290 · 2 episodes

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24. —
    Simon Sinek

    These Are Not Uncertain Times: Ways to Pivot, Lead and Thrive – Simon Sinek with Dave Asprey : 740 · Sep 2020

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25. —
    Scott Barry Kaufman

    The Hidden Cost of Being Too Nice: Why People-Pleasing is Silently Killing Your Success | Scott Barry Kaufman : 1261 · 2 episodes

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26. —
    Joe Hudson

    How to Make Life-Changing Decisions Without Fear – Joe Hudson : 1314 · Aug 2025

    0 votes

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27. —
    Gabrielle Lyon

    Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405 · 3 episodes

    0 votes

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28. —
    Ryan Holiday

    How to STOP Living in Fear and Find Your Purpose in Life | Ryan Holiday : 1236 · 3 episodes

    0 votes

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29. —
    Sarah Hill

    The Birth Control Episode: The Pill Isn’t Bulletproof – Sarah Hill, Ph.D. : 665 · Feb 2020

    0 votes

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30. —
    Tara Swart

    Learn How to Direct Your Brain’s Pathways – Dr. Tara Swart : 647 · Nov 2019

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31. —
    Esther Perel

    Sex, Marriage, & Business: Relationship Therapy With Esther Perel - #446 : 446 · Nov 2017

    0 votes

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32. —
    Rick Hanson

    Hacking Enlightenment in 7 Steps: The Dharma and Next-Gen of Neuroscience – Rick Hanson, Ph.D., with Dave Asprey : 696 · 2 episodes

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33. —
    Daniel Amen

    The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358 · 8 episodes

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34. —
    Ethan Kross

    How to Control, Reframe and Change the Chatter in Your Head! – Ethan Kross, Ph.D. : 1072 · 2 episodes

    0 votes

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35. —
    Tony Robbins

    Tony Robbins on the Ultimate Secrets to Wealth, Mindset, and Success : 1250 · 4 episodes

    0 votes

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36. —
    Adam Grant

    The Nuance of No – Adam Grant, Ph.D. : 577 · Mar 2019

    0 votes

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37. —
    Matthew Walker

    Sleep Smarter, Live Longer: Matthew Walker and Sleep Experts share Secrets to Better Sleep Performance : 1206 · 3 episodes

    0 votes

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38. —
    Vani Hari

    Kids vs. Big Food: Food Babe’s Playbook for Healthy Choices - Vani Hari : 1099 · Oct 2023

    0 votes

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39. —
    Calley Means

    Reversing The American Food Pyramid | Calley Means : 1395 · 2 episodes

    0 votes

    Never again
40. —
    Jamil Zaki

    Rewiring Your Brain for Hope: How to Overcome Cynicism with Dr. Jamil Zaki : 1197 · 3 episodes

    0 votes

    Never again